The dose makes the poison latin sola dosis facit venenum is an adage intended to indicate a basic principle of toxicology it is credited to paracelsus who expressed the classic toxicology maxim all things are poison and nothing is without poison the dosage alone makes it so a thing is not a poison. The dose makes the poison hich would you prefer to drink a cup of caffeine or a cup of trichloroethylene chances are good that your response was caf feine caffeine occurs naturally in coffee tea and chocolate and it is added to sodas and other types of drinks and foods trichloroethylene on. This is often condensed to the dose makes the poison it means that a substance that contains toxic properties can cause harm only if it occurs in a high enough concentration in other words any chemical even water and oxygen can be toxic if too much is ingested or absorbed into the body. The dose makes the poison is more than just an introduction to toxicology it is an enjoyable read with lots of interesting stories and one i can thoroughly recommend chemistry industry 25 july 2011. The dose makes the poison is a phrase which refers to the fact that whether a substance causes toxic effects depends on how much of it is taken a toxic substance is harmless if taken in small enough quantities and a harmless one can be poisonous if taken in large enough quantities
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